An Unexpected Conception: Spontaneous Pregnancy Following Bone Marrow Transplantation

Abstract

Haematopoietic stem cell transplantation (HSCT) following chemotherapy and radiotherapy is a potentially curative treatment for haematological malignancies but is frequently associated with gonadotoxicity, premature ovarian insufficiency (POI), and infertility. Prolonged amenorrhoea with biochemical evidence of ovarian failure is common among female transplant recipients, and many do not regain ovarian function. We describe a case of spontaneous pregnancy in a woman with longstanding amenorrhoea following intensive oncological treatment and allogeneic bone marrow transplantation...